Motif ID: HOX{A5,B5}.p2

Z-value: 2.298


Transcription factors associated with HOX{A5,B5}.p2:

Gene SymbolEntrez IDGene Name
HOXA5 3202 homeobox A5
HOXB5 3215 homeobox B5



Activity profile for motif HOX{A5,B5}.p2.

activity profile for motif HOX{A5,B5}.p2


Sorted Z-values histogram for motif HOX{A5,B5}.p2

Sorted Z-values for motif HOX{A5,B5}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A5,B5}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_5289079 4.665 NM_001040661
NM_153247
SLC29A4

solute carrier family 29 (nucleoside transporters), member 4

chr6_+_33495824 3.703 NM_006772
SYNGAP1
synaptic Ras GTPase activating protein 1
chr20_-_48741481 2.945


chr1_+_196874867 2.853 PTPRC
protein tyrosine phosphatase, receptor type, C
chr17_-_72151314 2.831 NM_018414
ST6GALNAC1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
chr12_+_53241365 2.696 NM_001165975
PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr20_-_55533544 2.595 NM_080618
CTCFL
CCCTC-binding factor (zinc finger protein)-like
chr1_-_143706196 2.512 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_+_144124547 2.483 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr1_+_26517032 2.361 CD52
CD52 molecule
chr8_+_21972804 2.355 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr1_-_143706265 2.316 PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_143706300 2.316 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr17_+_71109734 2.240 MYO15B
myosin XVB pseudogene
chr5_+_133870175 2.215


chr2_+_113648020 2.200 NM_012455
PSD4
pleckstrin and Sec7 domain containing 4
chr3_-_197549588 2.198 TM4SF19
transmembrane 4 L six family member 19
chr1_+_26516967 2.180 NM_001803
CD52
CD52 molecule
chr16_+_31446703 2.112 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr11_+_4621731 2.111 NM_152430
OR51E1
olfactory receptor, family 51, subfamily E, member 1
chr1_+_26517045 2.078 CD52
CD52 molecule
chr8_+_21972631 1.908 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr22_-_21231421 1.896 NM_206955
NM_206956
NM_006115
NM_206953
NM_206954
PRAME




preferentially expressed antigen in melanoma




chr1_+_202000906 1.858 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr19_+_45797413 1.798 LTBP4
latent transforming growth factor beta binding protein 4
chr3_-_197549640 1.643 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr2_+_113648036 1.632 PSD4
pleckstrin and Sec7 domain containing 4
chr1_-_154215558 1.612 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr11_+_5573906 1.599 NM_058166
TRIM6
tripartite motif containing 6
chr19_-_54958326 1.577 NM_021733
TSKS
testis-specific serine kinase substrate
chr1_-_26517342 1.572 NM_145345
UBXN11
UBX domain protein 11
chr1_+_20385164 1.566 NM_152376
UBXN10
UBX domain protein 10
chr3_-_122862447 1.555 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr19_+_55844446 1.468 NM_001195076
LOC342918
hypothetical protein LOC342918
chr11_+_4859624 1.464 NM_001004759
OR51T1
olfactory receptor, family 51, subfamily T, member 1
chr20_+_44083667 1.418 NM_001134771
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr17_-_36276987 1.383 NM_000223
KRT12
keratin 12
chr17_+_53769659 1.350 LOC100506779
hypothetical LOC100506779
chr1_-_36338436 1.339 NM_005202
COL8A2
collagen, type VIII, alpha 2
chr1_-_153444304 1.339 NM_007112
THBS3
thrombospondin 3
chrX_+_48265107 1.293 NM_006579
EBP
emopamil binding protein (sterol isomerase)
chr11_+_5574440 1.278 NM_001003818
NM_001198644
NM_001198645
NM_001003819
TRIM6


TRIM6-TRIM34
tripartite motif containing 6


TRIM6-TRIM34 readthrough
chr19_-_13074513 1.274 LYL1
lymphoblastic leukemia derived sequence 1
chr6_+_31976754 1.273 NM_001178063
C2
complement component 2
chr11_+_63030099 1.259 NM_001142535
NM_001142536
NM_033101
LGALS12


lectin, galactoside-binding, soluble, 12


chr1_+_111215343 1.250 NM_001040033
CD53
CD53 molecule
chr3_-_197023096 1.211 MUC4
mucin 4, cell surface associated
chr17_+_20712337 1.183


chr3_-_180460372 1.178 NM_171829
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr17_-_37590910 1.164 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr22_+_18388656 1.159 C22orf25
chromosome 22 open reading frame 25
chr8_-_95298706 1.158 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr6_+_34590624 1.151 PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr12_-_8110196 1.145 NM_004054
C3AR1
complement component 3a receptor 1
chr1_+_203503214 1.136 TMCC2
transmembrane and coiled-coil domain family 2
chr15_+_41597097 1.125 NM_002373
MAP1A
microtubule-associated protein 1A
chr3_+_39484073 1.104 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr2_+_74635019 1.099 NM_001381
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr22_+_21870293 1.099


chr19_-_47040347 1.086 NM_173506
LYPD4
LY6/PLAUR domain containing 4
chr22_-_25343959 1.078 NM_001887
CRYBB1
crystallin, beta B1
chr3_+_185300660 1.075 NM_182589
HTR3E
5-hydroxytryptamine (serotonin) receptor 3, family member E
chr12_+_54361596 1.069 NM_152637
METTL7B
methyltransferase like 7B
chrX_-_130251068 1.061 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr2_+_171381317 1.058 NM_000817
NM_013445
GAD1

glutamate decarboxylase 1 (brain, 67kDa)

chr19_-_56549853 1.057 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr16_+_29728932 1.048 MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr1_+_205694237 1.031 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chr9_-_85761472 1.029 NM_032307
C9orf64
chromosome 9 open reading frame 64
chr19_+_46207335 1.021 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr6_-_31890765 1.013 NM_005527
HSPA1L
heat shock 70kDa protein 1-like
chr12_+_7174230 1.006 NM_014718
CLSTN3
calsyntenin 3
chr11_-_56761250 1.006 NM_005161
APLNR
apelin receptor
chr19_+_8023887 1.001 NM_005624
CCL25
chemokine (C-C motif) ligand 25
chr22_+_18388633 0.999 C22orf25
chromosome 22 open reading frame 25
chr2_+_171381626 0.991 GAD1
glutamate decarboxylase 1 (brain, 67kDa)
chr22_-_49041786 0.965 MAPK12
mitogen-activated protein kinase 12
chr19_-_13074669 0.956 LYL1
lymphoblastic leukemia derived sequence 1
chr1_-_151867338 0.955 NM_005979
S100A13
S100 calcium binding protein A13
chr11_-_111287657 0.952 NM_001885
CRYAB
crystallin, alpha B
chr14_-_20128721 0.950 NM_001024822
RNASE12
ribonuclease, RNase A family, 12 (non-active)
chr20_+_42417502 0.947 HNF4A
hepatocyte nuclear factor 4, alpha
chr11_-_56905178 0.935 NM_006093
PRG3
proteoglycan 3
chr12_-_8110268 0.935 C3AR1
complement component 3a receptor 1
chr3_-_197023544 0.934 NM_004532
NM_018406
NM_138297
MUC4


mucin 4, cell surface associated


chr4_+_22608252 0.928


chr19_+_54621499 0.918 NM_001195256
LOC645971
hypothetical protein LOC645971
chrX_-_152863251 0.911 NM_002910
RENBP
renin binding protein
chr19_-_40925151 0.908 NM_024660
TMEM149
transmembrane protein 149
chr19_+_43847049 0.908


chr22_+_34979062 0.906 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr22_+_34979118 0.897 APOL1
apolipoprotein L, 1
chr8_-_141536992 0.873 TRAPPC9
trafficking protein particle complex 9
chr10_+_70745615 0.848 NM_033496
HK1
hexokinase 1
chr11_+_36274300 0.847 NM_001160167
PRR5L
proline rich 5 like
chr12_+_6800950 0.839 NM_014449
NM_019858
GPR162

G protein-coupled receptor 162

chr11_-_118055564 0.837 NM_007180
TREH
trehalase (brush-border membrane glycoprotein)
chrX_-_130250880 0.831 IGSF1
immunoglobulin superfamily, member 1
chr17_+_71141108 0.824 NM_001162995
LOC643008
hypothetical protein LOC643008
chr9_+_134843918 0.822 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr8_-_22841173 0.821 NM_144962
PEBP4
phosphatidylethanolamine-binding protein 4
chr1_-_120240635 0.815 NM_021794
ADAM30
ADAM metallopeptidase domain 30
chr17_-_7107229 0.810 NM_001185022
CLDN7
claudin 7
chrX_-_151672985 0.809 NM_005361
NM_175742
NM_175743
MAGEA2


melanoma antigen family A, 2


chr10_+_35524835 0.807 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chrX_-_152139267 0.804 NM_004988
MAGEA1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr6_+_44076281 0.798 NM_001171992
NM_153246
C6orf223

chromosome 6 open reading frame 223

chr1_-_155052562 0.795 NM_001161443
SH2D2A
SH2 domain containing 2A
chr19_-_54636425 0.792 NM_020309
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
chr12_+_54361685 0.787 METTL7B
methyltransferase like 7B
chr4_-_45820686 0.786 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr16_-_65984836 0.786 NM_015964
NM_016140
TPPP3

tubulin polymerization-promoting protein family member 3

chr8_-_66863841 0.782 NM_002603
PDE7A
phosphodiesterase 7A
chr6_-_29563657 0.781 NM_052967
MAS1L
MAS1 oncogene-like
chr17_-_39340414 0.781 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr17_+_53769562 0.771 LOC100506779
hypothetical LOC100506779
chr5_+_148766632 0.766 LOC728264
hypothetical LOC728264
chr11_+_72660894 0.762 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chrX_+_128700605 0.761 NM_003399
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr1_-_155053124 0.760 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr19_-_43919428 0.748 CAPN12
calpain 12
chr3_+_131547048 0.743 NM_153264
COL6A5
collagen, type VI, alpha 5
chr10_+_114125955 0.742 ACSL5
acyl-CoA synthetase long-chain family member 5
chr15_+_39008822 0.739 NM_019074
DLL4
delta-like 4 (Drosophila)
chr2_-_219881937 0.736 PTPRN
protein tyrosine phosphatase, receptor type, N
chr14_-_23090606 0.734 NM_033400
ZFHX2
zinc finger homeobox 2
chr2_-_167058829 0.732 SCN7A
sodium channel, voltage-gated, type VII, alpha
chr7_-_100077072 0.731 NM_003227
TFR2
transferrin receptor 2
chrX_-_151688850 0.726 NM_005362
MAGEA3
melanoma antigen family A, 3
chr6_-_50025115 0.723 NM_001166478
DEFB133
defensin, beta 133
chr1_-_26070330 0.718 NM_178422
PAQR7
progestin and adipoQ receptor family member VII
chr4_+_55218663 0.714 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr22_+_28206180 0.713 NM_021076
NEFH
neurofilament, heavy polypeptide
chr19_-_63550712 0.710 A1BG
alpha-1-B glycoprotein
chr19_-_56537189 0.709 NM_001163922
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr3_+_50279993 0.705 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr10_+_114125927 0.699 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_97391779 0.693 NM_001143957
NM_030784
GPR63

G protein-coupled receptor 63

chr12_+_48784057 0.690 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr2_-_144994038 0.680 ZEB2
zinc finger E-box binding homeobox 2
chr17_-_39340638 0.678 NM_005374
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr16_-_82633262 0.678 NM_001080442
SLC38A8
solute carrier family 38, member 8
chr12_+_69148120 0.675


chr16_+_2749934 0.672


chr10_+_35524060 0.664 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr9_-_131626261 0.662 NM_000113
TOR1A
torsin family 1, member A (torsin A)
chr2_-_167058901 0.657 SCN7A
sodium channel, voltage-gated, type VII, alpha
chrX_-_130250715 0.655 NM_001170963
IGSF1
immunoglobulin superfamily, member 1
chr4_-_175986952 0.652 NM_001042543
NM_006529
GLRA3

glycine receptor, alpha 3

chr1_-_12599934 0.646 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chrX_+_149612488 0.636 NM_003828
MTMR1
myotubularin related protein 1
chr6_-_31736488 0.631 NM_021184
C6orf47
chromosome 6 open reading frame 47
chr19_+_40824486 0.623 NM_014209
ETV2
ets variant 2
chr14_-_22596522 0.618 NM_022478
NM_144985
CDH24

cadherin 24, type 2

chr11_+_111313067 0.617 NM_001037954
DIXDC1
DIX domain containing 1
chr19_+_62434188 0.612 NM_001015879
NM_003160
NM_001015878
AURKC


aurora kinase C


chr6_-_29703725 0.609 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr2_-_144994349 0.609 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr1_-_90955365 0.608 NM_020063
BARHL2
BarH-like homeobox 2
chr3_+_9933763 0.608 NM_032732
NM_153460
NM_153461
IL17RC


interleukin 17 receptor C


chr1_+_108765634 0.606 LOC400768
hypothetical LOC400768
chr16_-_2776606 0.605 NM_152891
PRSS33
protease, serine, 33
chr7_+_142670624 0.599 NM_001143679
NM_001143680
NM_001143681
NM_015917
GSTK1



glutathione S-transferase kappa 1



chr5_-_34020445 0.597 NM_001012509
NM_016180
SLC45A2

solute carrier family 45, member 2

chr7_+_100310669 0.592 SRRT
serrate RNA effector molecule homolog (Arabidopsis)
chr12_-_123914219 0.586 SCARB1
scavenger receptor class B, member 1
chr1_+_148020869 0.586 NM_000566
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr7_+_100310658 0.585 SRRT
serrate RNA effector molecule homolog (Arabidopsis)
chr19_+_39437292 0.584 NM_014686
KIAA0355
KIAA0355
chr1_+_205736095 0.574 NM_000573
NM_000651
CR1

complement component (3b/4b) receptor 1 (Knops blood group)

chr1_+_154855709 0.573 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr1_-_28375722 0.566 NM_001164723
PTAFR
platelet-activating factor receptor
chr7_+_129807467 0.566 NM_001868
CPA1
carboxypeptidase A1 (pancreatic)
chr6_-_31977747 0.559 NM_181842
ZBTB12
zinc finger and BTB domain containing 12
chr6_+_31662954 0.558 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr1_+_160618143 0.557 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr2_-_74498351 0.557 NM_001145054
C2orf81
chromosome 2 open reading frame 81
chr1_+_12627152 0.556 NM_001013630
AADACL4
arylacetamide deacetylase-like 4
chr4_-_73653331 0.554 NM_014243
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr19_-_52614151 0.553 MEIS3
Meis homeobox 3
chr11_-_117600918 0.551 NM_001098526
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr16_-_2330594 0.547 ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chr20_+_32926452 0.543 ACSS2
acyl-CoA synthetase short-chain family member 2
chr8_-_141537035 0.541 NM_001160372
TRAPPC9
trafficking protein particle complex 9
chr11_+_63030131 0.541 LGALS12
lectin, galactoside-binding, soluble, 12
chr10_+_114126004 0.539 ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_54387732 0.538 ITGA7
integrin, alpha 7
chr22_+_19651446 0.534 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr17_-_53651586 0.534 NM_017777
MKS1
Meckel syndrome, type 1
chr19_+_56420181 0.533 CD33
CD33 molecule
chr1_+_116718011 0.532 NM_001160233
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_+_24701363 0.530 RCAN3
RCAN family member 3
chr1_-_41259973 0.530 NM_001168247
NM_144990
SLFNL1

schlafen-like 1

chr1_-_109853808 0.527 NM_020703
AMIGO1
adhesion molecule with Ig-like domain 1
chr18_-_41923571 0.523 ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr11_-_57038891 0.522 NM_001198810
SLC43A1
solute carrier family 43, member 1
chr7_+_156128431 0.520 NM_001184997
RNF32
ring finger protein 32
chr9_+_130231027 0.519 CERCAM
cerebral endothelial cell adhesion molecule
chr9_-_129580732 0.518 NM_170600
SH2D3C
SH2 domain containing 3C
chrX_+_114430547 0.512 NM_016383
LUZP4
leucine zipper protein 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.17 8.23e-04 GO:0065007 biological regulation
1.19 1.79e-02 GO:0050896 response to stimulus
1.16 1.93e-02 GO:0050789 regulation of biological process
1.37 2.39e-02 GO:0065008 regulation of biological quality

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 3.39e-02 GO:0071944 cell periphery
1.21 3.55e-02 GO:0005886 plasma membrane

Nothing significant found in function category.